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Data supporting the concept that cell components can respond to external frequencies with metabolic changes

In order for an electromagnetic field to activate a metabolic process in the body a field induced molecular change must occur. This section will discuss the
physical, chemical and electrical properties of proteins and how electrical fields can affect the molecular structures and functions of proteins. "It is at the atomic level that physical processes, rather than chemical reactions in the fabric of molecules, appear to shape the transfer of energy and the flow of signals in living systems (Adey, 1993a)."

Proteins are sophisticated molecules that play critical structural and functional roles in the cells. Proteins help provide cell structure, strength and flexibility. Proteins also have functional roles as signaling molecules in the processes of cell communication and as enzymes in the chemical reactions of cells. The functional properties of proteins in turn are dependent upon their three-dimensional structure (Grattarola et al., 1998).

Proteins that catalyze chemical reactions are called enzymes (Holyzclaw et al., 1991). The body's enzymes are natural catalytic molecules that promote chemical reactions without themselves being used up. Enzymes are specific for certain chemical substances because they recognize specific chemical structures both by their three-dimensional shape as well as by their chemical properties (Jespersen, 1997).

Proteins embedded in cell membranes that act as signal devices are called receptors. Receptors respond to chemical signals from the blood stream to initiate chemical pathways within the cells and to assist in the transport of materials into and out of cells (Nelson and Cox, 2000). The scientific data also shows that receptors also respond to electric fields (Adey, 1993a).

Enzymes and membrane receptors, like all proteins, are folded into 3-dimensional structures. The three-dimensional structure of a protein arises because each protein is composed of a unique ordered sequence of amino acids. The proteins of human cells are all made of chiral molecules called L-amino acids (Nelson and Cox, 2000).

The location and sequence of amino acids, the location and sequence of negative and positive charges, and the interaction of the protein with water and other biological molecules determines the three-dimensional structure of a protein at body pH (Grattarola et al., 1998; Nelson and Cox, 2000).

Linus Pauling was the first scientist to discover that specific sequences of amino acids in a protein can cause it to coil or wind itself and then take on a helical shape called an alpha-helix (Pauling, 1988). This structure is particularly prominent in proteins that are embedded in cell membranes (Nelson and Cox, 2000). In electrical terms coils and helices are inductors, transducers and antennas.
The coil-to-helix transition is a nonlinear phenomenon (Grattarola et al., 1998), which means that it can be triggered by absolutely miniscule amounts of energy.

The coil-to-helix transition is a cooperative phenomenon called a two-state function, which is characteristic of any type of electronic or biological device appropriate for information processing (Grattarola et al., 1998).

Enzymes and receptors are types of proteins that possess the ability to fluctuate back and forth between active and inactive states much like electrical switches that can either be set to an on or off positions. This cyclical movement between the active position and the rest position of these types of proteins involves a reversible shift in the distribution of electrical charges, which subsequently alters the 3-dimensional folding and chemical binding sites of these proteins. This alteration in protein folding, called a configurational or conformational change is accompanied by changes in both the chemical reactivity and the electrical properties of these proteins (Wuddel and Apell, 1995).

For many years biologists have recognized that the triggering mechanism that turns on enzymes and receptors causing them to transition between their active and rest states involves chemical interactions where chemical compounds transfer electrical charges between one another. However, new research has now proven that the transfer of electric charges does not always require a chemical carrier. In fact enzymes and receptors can also be activated by electric charges directly transferred from resonantly coupled electric fields (Derényi and Astumian, 1998). This is because the intramolecular charge transfer that occurs in enzymes and receptors undergoing conformational transitions within their cycle conveys to these molecules the ability to transduce energy directly from oscillating electric fields (Astumian et al., 1989).

A number of researchers, especially Ross Adey, have shown that weak electromagnetic fields may resonantly interact with the glycoproteins of the cell membrane acting like first messenger signals that activate intracellular enzymes (Adey, 1993b). These electromagnetic signals can create conformational changes in cell membrane proteins when these membrane proteins transductively couple with electromagnetic frequencies provided the frequencies are within certain amplitude and frequency windows (Adey, 1993b). This means the cell membrane proteins can act like electrical transducers that behave as on off electrical switches that activate chemical processes inside of the cell (Adey, 1980, 1981, 1988, 1993b; Adey et al., 1982).

"The essential molecular functions appear in fact to be determined by electromagnetic mechanisms. A possible role of molecular structures would be the carrying of electric charges, which generate, in the aqueous environment, a field specific to each molecule. Those exhibiting such coresonating or opposed fields ("electroconformational coupling") could thus communicate, even at a distance (Benveniste, 1993)."

For example, it is well recognized by biologists that cell enzymes such as Na, K-ATPases require energy to pump ions such as sodium and potassium across cell membranes. However, new data shows that these enzymes can either be activated by chemical energy derived from ATP or by energy directly absorbed from electric fields (Xie et al., 1997). In this case energy from the electric field substitutes for the energy normally provided chemically by ATP (Derényi and Astumian, 1998). Any electromagnetic effect on a chemically based biological reaction in the body is dependent upon the electric or magnetic frequency sensitivity of the rate constant of the enzyme involved in the chemical reaction (Weaver et al., 2000). Membrane receptor proteins can also be activated by resonantly coupling to electric fields (Astumian and Robertson, 1989).

"If fields can affect enzymes and cells, [one should expect] to be able to tailor a waveform as a therapeutic agent in much the same way as one now modulates chemical structures to obtain pharmacological selectivity and perhaps withhold many of the side-effects common to pharmaceutical substances (Davey and Kell, 1990)."

The key step necessary for this mechanism to work is to produce an electric field in the body, which exactly matches the resonant frequency of the enzymatic process or membrane receptor that you wish to stimulate so that the enzyme or receptor is able to resonantly couple to the field. This is exactly how LifeWave LIFEWAVE patches work.



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